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In the authors anecdotal experience, when further uptitration is not tolerated, but treatment effects are noted, maintaining the patient at the lower tolerated dose may be preferable to discontinuation

Detoxifies the Liver Through GST enzymes, it binds to toxins, drugs, and pollutants to make them water-soluble for excretion

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After 48 weeks of treatment, the results were: -2.1% for the placebo group, -8.7% for the 1 mg group, -17.1% for the combined 4 mg group, -22.8% for the combined 8 mg group, and -24.2% for the 12 mg group

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In 8-12 weeks , the above changes become more apparent